San Francisco 49ers vs. Minnesota Vikings Prediction, Odds, Moneyline – 09/15/2024 | 2024-2025 NFL Season
The San Francisco 49ers will face off against the Minnesota Vikings at U.S. Bank Stadium this Sunday afternoon. The 49ers lead the NFC West following a strong season opener, while the Vikings, who also won their first game, are currently on top of the NFC North. According to recent betting trends, the Minnesota Vikings are favored to win this matchup.
Game Details:
- Date: September 15, Sunday
- Time: 1:00 p.m. Eastern Time
- Location: U.S. Bank Stadium, Minneapolis, Minnesota
- TV: ABC/ESPN
- Stream: NFL+/Fubo TV
Odds and Betting Lines:
- Moneyline: San Francisco 49ers (-275) vs. Minnesota Vikings (+220)
- Spread: San Francisco 49ers (-6 -110) vs. Minnesota Vikings (+6 -110)
- Total (O/U): 45.5
San Francisco 49ers Overview: The 49ers started their season with a solid win over the New York Jets, finishing 32-19. Quarterback Brock Purdy threw for 231 yards, completing 19 of 29 passes. Jordan Mason was a standout in the running game with 147 yards on 28 carries and one touchdown. On defense, Jauan Jennings led the receiving corps with five catches for 64 yards.
Top Performers for San Francisco 49ers:
- Brock Purdy: 231 yards, 0 TD, 0 INT
- Jordan Mason: 28 carries, 147 yards, 1 TD
- Jauan Jennings: 5 receptions, 64 yards
Minnesota Vikings Overview: The Vikings dominated the New York Giants in their opener, winning 28-6. Sam Darnold led the team with 208 passing yards, completing 19 of 24 passes with two touchdowns and one interception. Aaron Jones added 94 rushing yards on 14 carries and a touchdown. Justin Jefferson led the receiving group with four catches for 59 yards and one touchdown.
Top Performers for Minnesota Vikings:
- Sam Darnold: 208 yards, 2 TD, 1 INT
- Aaron Jones: 14 carries, 94 yards, 1 TD
- Justin Jefferson: 4 receptions, 59 yards, 1 TD
Injury Report:
- San Francisco 49ers: Jack Conklin (G) is on IR, Christian McCaffrey (RB) is questionable with a calf injury, and Yetur Gross-Matos (DE) is also questionable with a knee issue. Jauan Jennings (WR) has returned from an ankle injury.
- Minnesota Vikings: Dalton Risner (T) and Jordan Kunaszyk (LB) are on IR. Jordan Addison (WR) is questionable with an ankle injury.
Betting Trends:
- San Francisco 49ers: The total has gone over in 4 of their last 5 games. They are 10-3 SU in their last 13 games but have struggled on the road against the Vikings, losing their last 7 road games in Minnesota.
- Minnesota Vikings: The total has gone over in 4 of their last 5 games. Despite a strong home record against San Francisco, the Vikings are 2-9 ATS in their last 11 home games.
Summary and Prediction: Both teams enter this game with strong performances in their openers. The Vikings, benefiting from home-field advantage and a robust performance in their debut, are expected to edge out the 49ers. Football experts predict a close contest with the Vikings narrowly winning 23-22.



